Identification of CD114 Membrane Receptors as a Molecular Target in Medulloblastomas

Medulloblastomas are the most common solid tumors in children, accounting for 8–30%. They are high-grade tumors with aggressive behavior and typically poor prognoses. Treatment includes surgery, chemotherapy, and radiotherapy, and presents high morbidity. Significant clinical, genetic, and prognostic differences exist between the four molecular subgroups: WNT, SHH, Group 3, and Group 4. Many studies seek to develop new chemotherapeutic agents for medulloblastomas through the identification of genes whose expressions are new molecular targets for drugs, such as membrane receptors associated with cell replication. This study assesses the association of CD114 expression with mortality in patients with medulloblastoma.