Molecular Basis of Distant Medulloblastoma

Molecular Basis of Distant Medulloblastoma

We read with interest a case report of medulloblastoma (MB) with delayed recurrence in an unusual area in an 11-year-old male patient. Distant MB metastases usually show leptomeningeal spread. However, Singh et al. describe a recurrent tumor arising from the frontal horn without leptomeningeal involvement. The authors discuss the possibility that the use of a ventriculoperitoneal shunt in the ventricles may have reversed the flow of cerebrospinal fluid, facilitating tumor cell travel. However, the possibility that a new lesion will appear in a distant area seems remote.